Researchers have developed a sulfonium-cross-linked hyaluronic acid-based hydrogel that serves as both an antibiotic carrier and an antimicrobial agent. This hydrogel can encapsulate antibiotics and release them in response to bacterial enzymes. It has shown effectiveness against antibiotic-resistant bacterial strains, including MRSA, VRE, and Pseudomonas aeruginosa. The hydrogel also demonstrated the ability to eradicate bacterial biofilms and counteract antibiotic resistance mechanisms.
Facts
- The study focuses on combating antibiotic-resistant bacteria by enhancing the activity of FDA-approved antibiotics using a carrier.
- The researchers developed a hyaluronic acid-based polymer, HA-SS-HA, which can encapsulate antibiotics and release them in response to bacterial enzyme hyaluronidase.
- Antibiotics such as vancomycin, amoxicillin, and tetracycline were encapsulated in the HA-SS-HA hydrogel, restoring their activity against antibiotic-resistant bacterial strains.
- The hydrogel was effective against MRSA, VRE, and Pseudomonas aeruginosa.
- It also demonstrated the ability to eliminate mature biofilms of Staphylococcus aureus and counteract antibiotic resistance mechanisms in bacterial cells.
- In vivo studies on mice showed excellent wound-healing activity of the hydrogel.
- The hydrogel could effectively combat Gram-negative, Gram-positive, and antibiotic-resistant bacterial strains, making it a valuable strategy against antibiotic-resistant bacteria.
- Antibiotic Resistance Challenge: Antibiotic resistance is a global health threat, limiting treatment options for infectious diseases.
- Novel Polymer Development: The study introduces a sulfonium-cross-linked hyaluronic acid-based polymer (HA-SS-HA) designed to serve as both an antimicrobial agent and an antibiotic carrier.
- Stimuli-Responsive Release: HA-SS-HA polymer can release antibiotics in response to hyaluronidase produced by bacterial cells.
- Effective Against Resistant Bacteria: The polymer successfully restored the activity of antibiotics against antibiotic-resistant strains, including MRSA, VRE, and Pseudomonas aeruginosa.
- Biofilm Eradication: The HA-SS-HA hydrogel demonstrated strong efficacy in eradicating mature bacterial biofilms.
- In Vivo Wound Healing: In animal studies, HA-SS-HA exhibited excellent wound-healing properties.
- Broad-Spectrum Antibacterial Activity: The polymer could effectively combat Gram-negative, Gram-positive, and antibiotic-resistant bacterial strains.
In the battle against antibiotic-resistant bacteria, researchers have developed a versatile hyaluronic acid-based hydrogel called HA-SS-HA. This hydrogel serves as an antibiotic carrier, capable of encapsulating antibiotics like vancomycin, amoxicillin, and tetracycline. What sets this hydrogel apart is its ability to release antibiotics in response to the presence of a bacterial enzyme called hyaluronidase. This responsive release profile enables the hydrogel to restore the activity of antibiotics against antibiotic-resistant strains, including MRSA, VRE, and Pseudomonas aeruginosa. Additionally, the hydrogel demonstrated its effectiveness in eradicating mature bacterial biofilms and counteracting antibiotic resistance mechanisms in bacterial cells. In vivo studies on mice also revealed its potential for wound healing. This development offers a promising and economically effective strategy to combat antibiotic-resistant bacterial strains.
The researchers emphasize the importance of addressing the growing threat of antibiotic-resistant bacterial infections. They highlight the development of sulfonium-containing antibiotic carriers as a potential solution, given their superior antibacterial activity and reduced toxicity to host cells. The study aims to streamline the process of developing effective antibiotic carriers and ultimately contribute to the fight against antibiotic-resistant superbugs.
Study by @DebasisMannaCH that developed a self-healing hyaluronic acid-based #hydrogel to combat #antibiotic-resistant #bacteria, restoring antibiotic efficacy and promoting wound healing. https://t.co/a5edJrZGad pic.twitter.com/RG4guelhoO
— RJ (@researchersjob) November 3, 2023
In a groundbreaking study, scientists have unveiled a novel approach to combat antibiotic-resistant bacteria, offering hope in the battle against the growing threat of superbugs. The research team developed a unique hyaluronic acid-based hydrogel, known as HA-SS-HA, which acts as both an antibiotic carrier and an antimicrobial agent. This innovative hydrogel has the ability to encapsulate antibiotics such as vancomycin, amoxicillin, and tetracycline, and release them in response to the presence of a bacterial enzyme called hyaluronidase. The results are nothing short of remarkable, as the hydrogel effectively restored the activity of these antibiotics against antibiotic-resistant strains like MRSA, VRE, and Pseudomonas aeruginosa. Additionally, the hydrogel demonstrated its power to eliminate mature bacterial biofilms and counteract antibiotic resistance mechanisms in bacterial cells. In vivo studies on mice further showcased its potential for wound healing. With the development of this multifaceted hydrogel, researchers have unveiled an economically effective strategy to combat antibiotic-resistant bacterial strains, offering a glimmer of hope in the battle against these formidable adversaries.
- Anjali Patel, Sanghamitra Goswami, Gunanka Hazarika, Senthilkumar Sivaprakasam, SurajitBhattacharjee,*and Debasis Manna
- Antibiotic-resistant bacteria
- HA-SS-HA hydrogel
- Stimuli-responsive drug carrier
- Wound healing efficacy
- Biofilm eradication
