A study reports on the synthesis, stability, chemical transformations, protein interaction, and cytotoxicity of a series of non-oxido [VIV(L1−4)2] complexes with dithiocarbazate ligands. The results show the formation of a mixture of [VIV(L1−4)2], [VV(L1−4)2]+, and [VVO2(L1−4)2]− species, which may contribute to the observed biological activity.
“🔬 Exciting new research explores non-oxido [VIV(L1−4)2] complexes with dithiocarbazate ligands! 🧪 The study investigates their synthesis, stability, chemical transformations, protein interactions, and cytotoxicity. These rare vanadium(IV) complexes show potential biological activity and may contribute to therapeutic effects. Read more about this fascinating research: #Science #Chemistry #Biomedical #Research”
Facts
- 💡 Vanadium is an important trace element in biological systems and has therapeutic effects.
- 💡 Interaction with proteins, particularly serum albumins, plays a crucial role in the pharmaceutical and biomedical applications of metal complexes.
- 💡 Non-oxido vanadium(IV) complexes formed by ONS/SS/OS donor ligands are relatively rare.
- 💡 Dithiocarbazate ligands have gained attention due to their ligation properties and potential applications in pharmacology and medicine.
- 💡 The study presents the synthesis and characterization of a new series of non-oxido vanadium(IV) complexes with S-alkyl/aryl substituted dithiocarbazate ligands.
- 💡 The stability of the complexes in solution and their interaction with bovine serum albumin (BSA) are investigated.
- 💡 The complexes are tested for their cytotoxic activity against colon cancer, cervical cancer, and mouse embryonic fibroblast cell lines.
Vanadium is an essential trace element with biological relevance, found in enzymes and involved in various metabolic processes. The therapeutic effects of vanadium compounds have been explored, and the relationship between their structure and activity has been investigated. Protein interactions are crucial in biomedical applications, and serum albumins, the major soluble proteins in the blood, can influence the circulatory half-life of metallodrugs. Oxidovanadium(IV) complexes have exhibited promise as anticancer medication. Nevertheless, the biological processes of hydrolysis, ligand exchange, and redox reactions have made it difficult to comprehend their biochemical behaviors.Non-oxido vanadium(IV) complexes, particularly those formed by ONS/SS/OS donor ligands, are relatively rare compared to oxido species. Dithiocarbazate ligands have gained attention due to their ligation properties, and their transition metal complexes have potential applications in pharmacology and medicine. In this study, a series of non-oxido vanadium(IV) complexes with S-alkyl/aryl substituted dithiocarbazate ligands is synthesized and characterized. The stability of the complexes in solution is investigated, along with their interaction with bovine serum albumin. Furthermore, the complexes are evaluated for their cytotoxic activity against colon cancer, cervical cancer, and mouse embryonic fibroblast cell lines.
- Atanu Banerjee, Sushree Aradhana Patra, Gurunath Sahu, Giuseppe Sciortino, Federico Pisanu, Eugenio Garribba, M. Fernanda N.N. Carvalho, Isabel Correia, João Costa Pessoa, Hans Reuter, and Rupam Dinda*
- Publication Date:May 8, 2023
- Inorg. Chem. 2023, 62, 20, 7932–7953
- https://doi.org/10.1021/acs.inorgchem.3c00753
