A virus that causes cancer The Epstein Barr Virus (EBV) can affect neuronal cells and cause numerous alterations to biomolecules like fatty acids, carbohydrates, and protein building blocks.
Brain tumors and illnesses of the central nervous system could result from this. The research has been published in the ACS Chemical Neuroscience journal.
- Researchers from IIT Indore have found that the cancer-causing Epstein Barr Virus (EBV) can infect neuronal cells and cause changes in biomolecules like fatty acids, carbohydrates, and protein. This can lead to diseases of the central nervous system and brain cancer.
- People all over the world have been found to have the EBV virus.
- But scientists still don’t know how this virus can affect and control brain cells.
- They showed that different biomolecules in neuronal cells could change gradually over time when viruses were present.
- They saw that the number of lipid, cholesterol, proline and glucose molecules in the cells increased when viruses were present.
Researchers from IIT Indore have found that the cancer-causing Epstein Barr Virus (EBV) can infect neuronal cells and cause changes in biomolecules like fatty acids, carbohydrates, and protein. This can lead to diseases of the central nervous system and brain cancer. The study was published in the journal ACS Chemical Neuroscience.
The EBV virus is common in the human population. It usually doesn’t harm, but the virus can become active inside the body in unusual situations like immunological stress or immunocompetence. This can lead to problems like Burkitt’s lymphoma, stomach cancer, multiple sclerosis, etc. Earlier studies provided links to EBV involvement in various neurodegenerative diseases. But no one knows how this virus can affect and control the brain cells.
The researchers used the Raman microspectroscopy method, supported by the Department of Science and Technology (DST) under the FIST scheme, to find out how a virus that causes cancer might affect brain cells. The technique based on the Raman Effect is a simple, low-cost way to find chemical changes in biological samples.
They showed that viruses could cause changes in the biomolecules of neuronal cells that happened over time. Also, these changes were different from what was seen in other supportive brain cells (that is, astrocyte and microglia).
The group leader of the Infection Bioengineering group at IIT Indore, Dr. Hem Chandra Jha, and his students Omkar Indari, Shweta Jakhmola, and Meenakshi Kandpal, along with the group leader of the Material and Device Laboratory (Department of Physics), Professor Rajesh Kumar, and a team that included Dr. Devesh K. Pathak and Ms. Manushree Tanwar, found that these cells sometimes changed in
They saw that the number of lipid, cholesterol, proline and glucose molecules increased in the cells when viruses were present.