The technology makes the RBCs in the lab into smaller biocompatible vesicles. If you put a drug in the particle’s lipid bilayer, the drug can stay there and circulate for a longer time. It will make treatment more personalized and also lessen the side effects.
- New technology for chemotherapy applications uses the red blood cell membrane developed by the Indian Institute of Technology (IIT Delhi).
- Cellular engineering in the laboratory produces biocompatible vesicles that are smaller than RBCs.
- According to IIT Delhi officials, “Drug molecules can be trapped inside the particle’s lipid bilayer and circulate for a longer period.
Researchers at the Indian Institute of Technology (IIT) Delhi have developed a way to use the red blood cell membrane to make chemotherapy more personalized and less likely to cause side effects. According to senior people at the institute, the technology makes the RBCs in the lab into smaller biocompatible vesicles. “In this case, drug molecules can just get stuck inside the particle’s lipid bilayer and stay there for a long time. At the moment, few synthetic nanoparticles used in nanomedicine have short circulation times and are often linked to general toxicity, “They said that.
Research by professor Neetu Singh and Sahil Malhotra from the Centre for Biomedical Engineering at the Indian Institute of Technology Delhi (IT Delhi) uses the long-circulating nature of the RBCs to solve a long-standing problem with drug delivery. This means that the drug can stay in the body for a long time without being recognized by immune cells. Singh said that when he looked into the research more, “The idea here is to use the body’s cells to load multiple drugs at the same time and reach the tumor sites in high concentrations. This nano-RBCs platform has a lot of the same properties as other polymers or liposomes, but they are more effective.”
We were interested in nature’s oxygen delivery vehicle, the RBCs, because these are also the longest-lasting cells in the body. However, it is hard to control a natural system’s physical and chemical properties in the same way that we can control a synthetic system. Over the last few years, we have shown that RBCs can be used to deliver drugs, and we have found ways to make the naturally-formed vesicles work for different things.